2'-脱氧-5-羟甲基尿甙
| CAS号 | 5116-24-5 | 货号 | BCP38821 |
| 中文名 | 2'-脱氧-5-羟甲基尿甙 | ||
| 英文名 | 5-Hydroxymethyl-2'-deoxyuridine | ||
| 中文别名 | 5-羟甲基尿嘧啶脱氧核苷;5-羟甲基脱氧尿苷; | ||
| 英文别名 | alpha-Hydroxythymidine;5-Hydroxymethyldeoxyuridine; | ||
| 分子式 | C10H14N2O6 | 分子量 | 258.23 |
| 生物活性 | 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HSV | ||
结构式
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