Fludrocortisone acetate
CAS No. | 514-36-3 | Cat. No. | BCP38927 |
Name | Fludrocortisone acetate | ||
Synonyms | Fludrocortisone 21-acetate; | ||
Formula | C23H31FO6 | M. Wt | 422.49 |
Description | Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. | ||
Pathways | GPCR/G Protein | ||
Targets | Glucocorticoid Receptor |
Structure
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