XE 991
| CAS No. | 122955-42-4 | Cat. No. | BCP39201 |
| Name | XE 991 | ||
| Synonyms | XE991; XE-991; LS 190926; LS190926; LS-190926; | ||
| Formula | C26H20N2O | M. Wt | 376.45 |
| Description | XE 991 is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. XE 991 blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). XE 991 increases hippocampal ACh release and enhances cognition following oral administration in vivo, suggesting to be beneficial for Alzheimer's disease therapy. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel | ||
Structure
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