PXS5505
| CAS号 | 2409963-83-1 | 货号 | BCP39658 |
| 中文名 | PXS5505 | ||
| 英文名 | PXS5505 | ||
| 中文别名 | |||
| 英文别名 | PXS-5505;PXS 5505;LOX-IN-3;LOXIN3,LOX IN 3; | ||
| 分子式 | C13H13FN2O2S | 分子量 | 280.32 |
| 生物活性 | Pan-LOX Inhibitor PXS-5505 is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (LOX) family members, with potential antifibrotic activity. Upon oral administration, pan-LOX inhibitor PXS-5505 targets, binds to and inhibits the activity of all enzymes in the LOX family. This prevents the post-translational oxidative deamination of lysine residues on target proteins, including collagen and elastin, and reduces the formation of deaminated lysine (allysine), the formation of inter- and intramolecular cross-linkages and may prevent remodeling of the extracellular matrix (ECM), thereby reducing fibrotic tissue formation in certain chronic fibrotic diseases. LOX is often upregulated in fibrotic tissue and plays a key role in fibrosis. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Lipoxygenase | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！