萘福昔定
| CAS号 | 1845-11-0 | 货号 | BCP39840 |
| 中文名 | 萘福昔定 | ||
| 英文名 | Nafoxidine | ||
| 中文别名 | |||
| 英文别名 | NSC 70735; NSC70735; NSC-70735; | ||
| 分子式 | C29H31NO2 | 分子量 | 425.56 |
| 生物活性 | Nafoxidine is a triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04) | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Estrogen Receptor | ||
结构式
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