Diphyllin
CAS No. | 22055-22-7 | Cat. No. | BCP39987 |
Name | Diphyllin | ||
Synonyms | |||
Formula | C21H16O7 | M. Wt | 380.35 |
Description | Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities. |
Structure
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