XL177A
| CAS号 | 2417089-74-6 | 货号 | BCP40918 |
| 中文名 | XL177A | ||
| 英文名 | XL177A | ||
| 中文别名 | |||
| 英文别名 | XL-177A; XL 177A; | ||
| 分子式 | C48H57ClN8O5 | 分子量 | 861.47 |
| 生物活性 | XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DUB | ||
结构式
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