U 18666A
| CAS No. | 3039-71-2 | Cat. No. | BCP41254 |
| Name | U 18666A | ||
| Synonyms | U 18666A; U18666A; U 18666 A; U-18666-A; NSC-70801; NSC 70801; NSC70801; | ||
| Formula | C25H42ClNO2 | M. Wt | 424.06 |
| Description | U 18666A is an inhibitor of cholesterol synthesis. It acts by inhibiting desmosterol Δ24-reductase. U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking. U18666A or other cholesterol transport inhibitor may be considered as the antiviral drug for the treatment of cats with FIP. U18666A accumulated intracellular free cholesterol in the culture of normal medium but not cholesterol-free medium. U18666A also induced reactive oxygen species (ROS) generation in normal medium but much less in cholesterol-free medium. | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | HCV Protease HCV | ||
Structure
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