U 18666A
| CAS号 | 3039-71-2 | 货号 | BCP41254 |
| 中文名 | U 18666A | ||
| 英文名 | U 18666A | ||
| 中文别名 | |||
| 英文别名 | U 18666A; U18666A; U 18666 A; U-18666-A; NSC-70801; NSC 70801; NSC70801; | ||
| 分子式 | C25H42ClNO2 | 分子量 | 424.06 |
| 生物活性 | U 18666A is an inhibitor of cholesterol synthesis. It acts by inhibiting desmosterol Δ24-reductase. U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking. U18666A or other cholesterol transport inhibitor may be considered as the antiviral drug for the treatment of cats with FIP. U18666A accumulated intracellular free cholesterol in the culture of normal medium but not cholesterol-free medium. U18666A also induced reactive oxygen species (ROS) generation in normal medium but much less in cholesterol-free medium. | ||
| 信号通路 | Protease/Metabolic Enzyme Microbiology/Virology | ||
| 靶 点 | HCV Protease HCV | ||
结构式
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