Viloxazine hydrochloride
| CAS号 | 35604-67-2 | 货号 | BCP41580 |
| 中文名 | Viloxazine hydrochloride | ||
| 英文名 | Viloxazine hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Viloxazine HCl; ICI 58,834; ICI-58,834; ICI58,834; ICI 58834; ICI-58834; ICI58834; SPN-812; SPN 812; SPN812; | ||
| 分子式 | C13H20ClNO3 | 分子量 | 273.76 |
| 生物活性 | Viloxazine is aselective norepinephrine reuptake inhibitor (NRI). Viloxazine was approved for medical use in the United States in April 2021 to treat attention deficit hyperactivity disorder (ADHD). Viloxazine, like imipramine, inhibited norepinephrine reuptake in the hearts of rats and mice; unlike imipramine, it did not block reuptake of norepinephrine in either the medullae or the hypothalami of rats. As for serotonin, while its reuptake inhibition was comparable to that of desipramine (i.e., very weak), viloxazine did potentiate serotonin-mediated brain functions in a manner similar to amitriptyline and imipramine, which are relatively potent inhibitors of serotonin reuptake. Unlike any of the other drugs tested, it did not exhibit any anticholinergic effects. | ||
| 上下游产品 | 46817-91-8（维洛沙秦） 56287-63-9（(R)-维洛沙嗪盐酸盐） 56287-61-7（(S)-维洛沙嗪盐酸盐） | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | Dopamine Receptor | ||
结构式
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