BAY-299
| CAS No. | 2080306-23-4 | Cat. No. | BCP41584 |
| Name | BAY-299 | ||
| Synonyms | BAY 299; BAY299; | ||
| Formula | C25H23N3O4 | M. Wt | 429.47 |
| Description | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). | ||
| Pathways | Epigenetics | ||
| Targets | Epigenetic Reader Domain | ||
Structure
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