Norleual

  • Chemical Properties
CAS No. 334994-34-2 Cat. No. BCP41927
Name Norleual
Synonyms L-Phenylalanine,L-norleucyl-L-tyrosyl-L-leucyl-y(CH2-NH)-L-histidyl-L-prolyl-;
Formula C41H58N8O7 M. Wt 774.95
  • Biological Activity
Description Norleual is an angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets c Met 

Structure

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