Oxocarbazate
| CAS No. | 1014405-03-8 | Cat. No. | BCP42707 |
| Name | Oxocarbazate | ||
| Synonyms | CID 23631927; CID23631927; CID-23631927; | ||
| Formula | C28H33N5O6 | M. Wt | 535.6 |
| Description | Oxocarbazate is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection. | ||
| Pathways | Microbiology/Virology | ||
| Targets | SARS CoV | ||
Structure
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