维罗非尼
| CAS号 | 1029872-54-5 | 货号 | BCP43160 |
| 中文名 | 维罗非尼 | ||
| 英文名 | Vemurafenib | ||
| 中文别名 | |||
| 英文别名 | PLX4032;PLX-4032;PLX 4032; | ||
| 分子式 | C23H18ClF2N3O3S | 分子量 | 489.92 |
| 生物活性 | Vemurafenib is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers. | ||
| 上下游产品 | 918504-65-1（维罗非尼） | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | Raf | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！