PF-06424439 HCl

  • Chemical Properties
CAS No. 1469284-80-7 Cat. No. BCP43813
Name PF-06424439 HCl
Synonyms PF06424439 HCl;PF 06424439 HCl;
Formula C22H27Cl2N7O M. Wt 476.41
  • Biological Activity
Description PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model.
Pathways Protease/Metabolic Enzyme 

Structure

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