ONC212
| CAS No. | 1807861-48-8 | Cat. No. | BCP44033 |
| Name | ONC212 | ||
| Synonyms | ONC-212; ONC 212; | ||
| Formula | C24H23F3N4O | M. Wt | 440.46 |
| Description | ONC212 is a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in >1000 human cancer cell lines in vitro and evaluated for safety and anti-tumor efficacy in vivo. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. | ||
| Pathways | Apoptosis Pathway | ||
Structure
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