Encorafenib
| CAS号 | 1269440-29-0 | 货号 | BCP44104 |
| 中文名 | Encorafenib | ||
| 英文名 | Encorafenib | ||
| 中文别名 | |||
| 英文别名 | LGX818; LGX-818; LGX 818; | ||
| 分子式 | C22H27ClFN7O4S | 分子量 | 540.01 |
| 生物活性 | Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | Raf | ||
结构式
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