PF-06459988

  • 化学数据
CAS号 1428774-45-1 货号 BCP44108
中文名 PF-06459988
英文名 PF-06459988
中文别名
英文别名 PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988;
分子式 C19H22ClN7O3 分子量 431.88
  • 用途
生物活性 PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
信号通路 Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway 
靶 点 EGFR 

结构式

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