PF-06459988
CAS号 | 1428774-45-1 | 货号 | BCP44108 |
中文名 | PF-06459988 | ||
英文名 | PF-06459988 | ||
中文别名 | |||
英文别名 | PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988; | ||
分子式 | C19H22ClN7O3 | 分子量 | 431.88 |
生物活性 | PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
靶 点 | EGFR |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!