RIPA-56
| CAS号 | 1956370-21-0 | 货号 | BCP44340 |
| 中文名 | RIPA-56 | ||
| 英文名 | RIPA-56 | ||
| 中文别名 | |||
| 英文别名 | RIPA56; RIPA 56; | ||
| 分子式 | C13H19NO2 | 分子量 | 221.3 |
| 生物活性 | RIPA-56 is a potent RIP1 inhibitor. RIPA-56 has RIP1 kinase IC50=13 nM; HT-29 Cell EC50 = 28 nM; in vivo PG: t1/2 = 3.1h. RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multiorgan damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | RIP | ||
结构式
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