安纳基林
| CAS号 | 486-89-5 | 货号 | BCP44368 |
| 中文名 | 安纳基林 | ||
| 英文名 | Anagyrin | ||
| 中文别名 | 安那吉碱;臭豆碱;臭豆鹼; | ||
| 英文别名 | Monolupine;Rhombinine; | ||
| 分子式 | C15H20N2O | 分子量 | 244.33 |
| 生物活性 | Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities. It binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2,096 µM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors. Anagyrine decreases survival of B. xylophilus worms. It inhibits proliferation of TE-671 and SH-SY5Y cancer cells. Maternal ingestion of anagyrine during gestation is associated with the teratogenic condition crooked calf disease in cattle. | ||
| 信号通路 | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| 靶 点 | nAChR | ||
结构式
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