Ertiprotafib
  • 化学数据
CAS号 251303-04-5 货号 BCP44500
中文名 Ertiprotafib
英文名 Ertiprotafib
中文别名
英文别名 PTP-112; PTP112; PTP 112;
分子式 C31H27BrO3S 分子量 559.52
  • 用途
生物活性 Ertiprotafib is an inhibitor of the protein tyrosine phosphatase 1B (PTP1B) and dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist with hypoglycemic and anti-lipidemic activity. Ertiprotafib inhibits PTP1B preventing the dephosphorylation of the insulin receptor, which improves insulin sensitivity and decreases blood glucose levels. In addition, this agent is able to stimulate both PPAR alpha and gamma thereby further improving glucose homeostasis and reducing triglyceride (TG) and free fatty acid levels. Ertiprotafib was also shown to be a potent inhibitor of IkappaB kinase beta (IKKbeta), which cotributes to its anti-inflammatory properties.
信号通路 Protease/Metabolic Enzyme 
靶 点 Phosphatase 

结构式

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