CL 316243
| CAS号 | 138908-40-4 | 货号 | BCP44544 |
| 中文名 | CL 316243 | ||
| 英文名 | CL 316243 | ||
| 中文别名 | |||
| 英文别名 | CL 316243; CL316243; CL-316,243; CL 316,243; CL316,243. HP 186; HP-186; HP186; | ||
| 分子式 | C20H18ClNO7.2Na | 分子量 | 465.79 |
| 生物活性 | CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. CL-316243 restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice. CL-316,243 enhances insulin-stimulated glucose disposal in nonobese rats. CL 316243 possesses anti-obesity and anti-diabetic effects and consequently may be useful for treating obesity as well as non-insulin-dependent diabetes mellitus in obese persons, without causing excessive side effects. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | Adrenergic Receptor | ||
结构式
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