MRTX1719
| CAS No. | 2630904-45-7 | Cat. No. | BCP44551 |
| Name | MRTX1719 | ||
| Synonyms | MRTX-1719;MRTX 1719; | ||
| Formula | C23H18ClFN6O2 | M. Wt | 464.89 |
| Description | MRTX1719 is a potent and selective binder to the PRMT5•MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells. Daily oral administration of MRTX1719 to tumor xenograft-bearing mice demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity. | ||
| Related Products | MRTX1719HCl（MRTX-1719 HCl） | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase | ||
Structure
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