Brecanavir
| CAS号 | 313682-08-5 | 货号 | BCP44630 |
| 中文名 | Brecanavir | ||
| 英文名 | Brecanavir | ||
| 中文别名 | |||
| 英文别名 | GW-0385; GW 0385; GW0385; GW-640385; GW 640385; GW640385; GW-640385X; VX-385; VX 385; VX385; | ||
| 分子式 | C33H41N3O10S2 | 分子量 | 703.82 |
| 生物活性 | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Brecanavir is by a substantial margin the most potent and broadly active antiviral agent among the PIs tested in vitro. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | HIV Protease | ||
结构式
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