Crisdesalazine
| CAS号 | 927685-43-6 | 货号 | BCP44811 |
| 中文名 | Crisdesalazine | ||
| 英文名 | Crisdesalazine | ||
| 中文别名 | |||
| 英文别名 | AAD-2004; AAD2004; AAD 2004; | ||
| 分子式 | C16H14F3NO3 | 分子量 | 325.28 |
| 生物活性 | Crisdesalazine, also known as AAD-2004, is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor potentially for the treatment of Alzheimer's type dementia, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Arthritis, Depression, Diabetes and Pancreatitis. AAD-2004 markedly suppressed neuronal loss and neuritic atrophy, and partially reversed depleted expression of calbindin in the brain of Tg-beta-CTF99/B6. AAD-2004 reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Prostaglandin Receptor | ||
结构式
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