VAS3947
| CAS No. | 869853-70-3 | Cat. No. | BCP44868 |
| Name | VAS3947 | ||
| Synonyms | VA S3947; VAS3947; | ||
| Formula | C14H10N6OS | M. Wt | 310.34 |
| Description | VAS3947 is a selective inhibitor of NADPH oxidase activity in low micromolar concentrations, interfering neither with ROS detection nor with XOD or eNOS activities. VAS3947 induces apoptosis in AML cells independently of its anti-NOX activity. VAS3947 thiol alkylates cysteine residues of glutathione (GSH), while also interacting with proteins. Remarkably, VAS3947 decreased detectable GSH in the MV-4-11 cell line, thereby suggesting possible oxidative stress induction. Overall, VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | NOX | ||
Structure
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