CCT020312
| CAS No. | 324759-76-4 | Cat. No. | BCP44907 |
| Name | CCT020312 | ||
| Synonyms | CCT-020312; CCT 020312; | ||
| Formula | C31H30Br2N4O2 | M. Wt | 650.42 |
| Description | CCT020312 is a potent and selective EIF2AK3 Activator. CCT020312 modulates the biological activity of EIF2AK3. CCT020312 sensitizes cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. CCT020312 is a novel small molecule chemical tool for the selective activation of EIF2A-mediated translation control with utility for proof-of-concept applications in EIF2A-centered therapeutic approaches, and as a chemical starting point for pathway selective agent development. CCT020312 is potent, and EIF2AK3 selective agent and can act as a sensitizer to chemotherapy-associated stresses as elicited by taxanes. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PERK | ||
Structure
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