L-778123
| CAS No. | 183499-57-2 | Cat. No. | BCP44918 |
| Name | L-778123 | ||
| Synonyms | L 778123; L778123; L-778,123; L 778,123; L778,123; | ||
| Formula | C22H20ClN5O | M. Wt | 405.88 |
| Description | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | FTase | ||
Structure
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