UNC6934
| CAS No. | 2561494-77-5 | Cat. No. | BCP45445 |
| Name | UNC6934 | ||
| Synonyms | UNC6934;UNC-6934; | ||
| Formula | C24H21N5O4 | M. Wt | 443.46 |
| Description | UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase | ||
Structure
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