8-Hydroxy-2'-deoxyguanosine

CAS No.	88847-89-6	Cat. No.	BCP45539
Name	8-Hydroxy-2'-deoxyguanosine
Synonyms	8-Oxo-2'-deoxyguanosine;8-Hydroxydeoxyguanosine;
Formula	C10H13N5O5	M. Wt	283.24

Description	8-Hydroxy-2'-deoxyguanosine is a major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative DNA damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dG can potentially mispair with deoxyadenine leading to G-to-T transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (SNPs) in the human genome. The concentration of 8-oxo-dG within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to DNA.
Pathways	Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis

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