Tyk2-IN-5
| CAS No. | 1797432-62-2 | Cat. No. | BCP45577 |
| Name | Tyk2-IN-5 | ||
| Synonyms | Tyk2 inhibitor 5; | ||
| Formula | C21H19FN8O2 | M. Wt | 434.43 |
| Description | Tyk2-IN-5 is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | JAK | ||
Structure
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