NSC697923
| CAS No. | 343351-67-7 | Cat. No. | BCP45754 |
| Name | NSC697923 | ||
| Synonyms | NSC 697923; NSC-697923; | ||
| Formula | C11H9NO5S | M. Wt | 267.26 |
| Description | NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | E1 E2 E3 Enzyme | ||
Structure
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