莫美他松
| CAS号 | 105102-22-5 | 货号 | BCP45832 |
| 中文名 | 莫美他松 | ||
| 英文名 | Mometasone | ||
| 中文别名 | 莫美达松; | ||
| 英文别名 | Mometasonum; | ||
| 分子式 | C22H28Cl2O4 | 分子量 | 427.36 |
| 生物活性 | Mometasone is a synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucocorticoid Receptor | ||
结构式
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