CI-976
| CAS No. | 114289-47-3 | Cat. No. | BCP45841 |
| Name | CI-976 | ||
| Synonyms | PD 128042;CI 976;PD-128042;PD128042;CI976; | ||
| Formula | C23H39NO4 | M. Wt | 393.56 |
| Description | CI 976 is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway. | ||
| Pathways | Protease/Metabolic Enzyme | ||
Structure
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