Tetomilast
| CAS号 | 145739-56-6 | 货号 | BCP45927 |
| 中文名 | Tetomilast | ||
| 英文名 | Tetomilast | ||
| 中文别名 | |||
| 英文别名 | OPC6535; OPC-6535; OPC 6535; | ||
| 分子式 | C19H18N2O4S | 分子量 | 370.42 |
| 生物活性 | Tetomilast, also known as OPC6535, is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Phosphodiesterase/PDE | ||
结构式
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