Ritlecitinib tosylate
  • 化学数据
CAS号 2192215-81-7 货号 BCP45991
中文名 Ritlecitinib tosylate
英文名 Ritlecitinib tosylate
中文别名
英文别名 PF-06651600; PF 06651600; PF06651600; PF-6651600; PF 6651600; PF6651600;
分子式 C22H27N5O4S 分子量 457.55
  • 用途
生物活性 Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies.
上下游产品 1792180-81-4（Ritlecitinib）
信号通路 Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics 
靶 点 JAK 

结构式

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