Bersacapavir
| CAS No. | 1638266-40-6 | Cat. No. | BCP46251 |
| Name | Bersacapavir | ||
| Synonyms | JNJ-6379; JNJ 6379; JNJ6379; JNJ-56136379; JNJ 56136379; JNJ56136379; JNJ-379; JNJ 379; JNJ379; | ||
| Formula | C16H14F4N4O3S | M. Wt | 418.37 |
| Description | Bersacapavir, also known as JNJ-6379, JNJ-56136379, or JNJ-379, a capsid assembly modulator that blocks hepatitis B virus (HBV) replication. JNJ-56136379 median 50% effective concentration (EC50) values across all genotypes were 10-33 nM versus 17 nM (genotype D reference). JNJ-56136379 remained active against isolates carrying nucleos(t)ide analogue resistance mutations (median EC50 2-25 nM) or basal core promoter (BCP) ± precore (PC) mutations (median EC50 13-20 nM) or PC mutations (median EC50 11 nM), representing activity against isolates from HBeAg-positive and -negative hepatitis B patients. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HBV | ||
Structure
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