WAY-204688
| CAS号 | 796854-35-8 | 货号 | BCP46376 |
| 中文名 | WAY-204688 | ||
| 英文名 | WAY-204688 | ||
| 中文别名 | |||
| 英文别名 | SIM-688; SIM 688; SIM688; WAY-204688; WAY 204688; | ||
| 分子式 | C34H31F3N2O2 | 分子量 | 556.63 |
| 生物活性 | WAY-204688, also known as SIM-688, is an estrogen receptor agonist and NF-κB inhibitor potentially for the treatment of rheumatoid arthritis. Preservation of mucosal weight and prevention of histopathologic changes were observed with the administration of WAY-204688. Similar findings were observed in a cecal ligation and puncture model with WAY-204688 and a related compound WAY-169916. These results indicate that oral administration of these pathway-selective ER ligands preserved gastrointestinal barrier function and improve outcome in experimental models of systemic infection and inflammation. These agents may prove to be useful clinically as a novel treatment strategy for severe sepsis. | ||
| 信号通路 | NFκB | ||
| 靶 点 | NF κB | ||
结构式
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