DX3-213B
| CAS No. | 2749555-66-4 | Cat. No. | BCP46463 |
| Name | DX3-213B | ||
| Synonyms | DX3213B; DX3 213B; | ||
| Formula | C20H28F2N2O5S2 | M. Wt | 478.57 |
| Description | DX3-213B is a potent Oxidative Phosphorylation Inhibitor (MIA PaCa-2 GI50 = 11 nM) for the Treatment of Pancreatic Cancer. DX3-213B disrupts adenosine triphosphate (ATP) generation, inhibits complex I function, and results in the growth inhibition of pancreatic cancer cells in the low nanomolar range. Importantly, the oral administration of DX3-213B resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Mitochondrial Metabolism | ||
Structure
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