LCH-7749944
| CAS号 | 796888-12-5 | 货号 | BCP46494 |
| 中文名 | LCH-7749944 | ||
| 英文名 | LCH-7749944 | ||
| 中文别名 | |||
| 英文别名 | LCH 7749944; LCH7749944; GNF-PF-2356; | ||
| 分子式 | C20H22N4O2 | 分子量 | 350.41 |
| 生物活性 | LCH-7749944 is a novel and potent PAK4 inhibitor, which effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway. In addition, LCH-7749944 significantly inhibited the migration and invasion of human gastric cancer cells in conjunction with concomitant blockage of PAK4/LIMK1/cofilin and PAK4/MEK-1/ERK1/2/MMP2 pathways. Interestingly, LCH-7749944 also inhibited the formation of filopodia and induced cell elongation in SGC7901 cells. Importantly, LCH-7749944 caused successful inhibition of EGFR activity due to its inhibitory effect on PAK4. Taken together, these results provided novel insights into the development of PAK4 inhibitor and potential therapeutic strategies for gastric cancer. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PAK | ||
结构式
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