JJKK048
| CAS号 | 1515855-97-6 | 货号 | BCP46517 |
| 中文名 | JJKK048 | ||
| 英文名 | JJKK048 | ||
| 中文别名 | |||
| 英文别名 | JJKK-048; JJKK 048; | ||
| 分子式 | C23H22N4O5 | 分子量 | 434.44 |
| 生物活性 | JJKK048 is an ultrapotent and highly selective inhibitors of monoacylglycerol lipase. JJKK-048 potently (IC50 < 0.4 nM) inhibited human and rodent MAGL. JJKK-048 displayed low cross-reactivity with other endocannabinoid targets. Monoacylglycerol lipase (MAGL) terminates the signaling function of the endocannabinoid, 2-arachidonoylglycerol (2-AG). During 2-AG hydrolysis, MAGL liberates arachidonic acid, feeding the principal substrate for the neuroinflammatory prostaglandins. In cancer cells, MAGL redirects lipid stores toward protumorigenic signaling lipids. Thus MAGL inhibitors may have great therapeutic potential. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | MAGL | ||
结构式
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