KSQ-4279
| CAS No. | 2446480-97-1 | Cat. No. | BCP46572 |
| Name | KSQ-4279 | ||
| Synonyms | KSQ 4279; KSQ4279;Usp1-IN-1; | ||
| Formula | C27H25F3N8O | M. Wt | 534.54 |
| Description | KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | PARP DUB | ||
Structure
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