AP1189
| CAS号 | 959850-73-8 | 货号 | BCP46590 |
| 中文名 | AP1189 | ||
| 英文名 | AP1189 | ||
| 中文别名 | |||
| 英文别名 | AP-1189;AP 1189; | ||
| 分子式 | C14H14N6O2 | 分子量 | 298.31 |
| 生物活性 | AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Melanocortin Receptor | ||
结构式
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