2-Hydroxyestrone

CAS No.	362-06-1	Cat. No.	BCP46743
Name	2-Hydroxyestrone
Synonyms	2-OHE1; 2OHE1; 2 OHE1;Catecholestrone;2-Hydroxy Estrone;
Formula	C18H22O3	M. Wt	286.37

Description	2-Hydroxyestrone is a metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and 1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic activity compared to the parent compound and other estrone metabolites. Additionally, O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent inhibitor of both cell proliferation and angiogenesis.
Pathways	Hormone Pathay
Targets	Estrogen Receptor

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