2-羟雌甾酮
| CAS号 | 362-06-1 | 货号 | BCP46743 |
| 中文名 | 2-羟雌甾酮 | ||
| 英文名 | 2-Hydroxyestrone | ||
| 中文别名 | 2-羟雌酮;2-羟基雌酚酮; | ||
| 英文别名 | 2-OHE1; 2OHE1; 2 OHE1;Catecholestrone;2-Hydroxy Estrone; | ||
| 分子式 | C18H22O3 | 分子量 | 286.37 |
| 生物活性 | 2-Hydroxyestrone is a metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and 1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic activity compared to the parent compound and other estrone metabolites. Additionally, O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent inhibitor of both cell proliferation and angiogenesis. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Estrogen Receptor | ||
结构式
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