KG5
| CAS No. | 877874-85-6 | Cat. No. | BCP46930 |
| Name | KG5 | ||
| Synonyms | KG-5; KG 5; | ||
| Formula | C20H16F3N7OS | M. Wt | 459.45 |
| Description | KG 5 is a PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase MAPK Pathway | ||
| Targets | PDGFR c Kit FLT3 Raf | ||
Structure
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