SJ10542
| CAS No. | SJ10542 | Cat. No. | BCP46974 |
| Name | SJ10542 | ||
| Synonyms | SJ 10542; SJ-10542; | ||
| Formula | C41H46N12O5S | M. Wt | 818.96 |
| Description | SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Others Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | PROTAC JAK | ||
Structure
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