CZC 54252 hydrochloride

  • Chemical Properties
CAS No. 1784253-05-9 Cat. No. BCP47285
Name CZC 54252 hydrochloride
Synonyms CZC-54252 HCl;CZC54252 HCl;CZC 54252 HCl;
Formula C22H26Cl2N6O4S M. Wt 541.45
  • Biological Activity
Description CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target.
Related Products 1191911-27-9(CZC-54252)
Pathways Others Pathway 
Targets LRRK2 

Structure

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