Lisaftoclax

CAS No.	2180923-05-9	Cat. No.	BCP47569
Name	Lisaftoclax
Synonyms	APG-2575;APG2575;APG 2575;Bcl-2/Bcl-xl inhibitor 1;
Formula	C45H48ClN7O8S	M. Wt	882.42

Description	Lisaftoclax is an orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.
Pathways	Apoptosis Pathway
Targets	Bcl2

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