(Z)-Thiothixene

  • Chemical Properties
CAS No. 3313-26-6 Cat. No. BCP48214
Name (Z)-Thiothixene
Synonyms CIS-Thiothixene;
Formula C23H29N3O2S2 M. Wt 443.63
  • Biological Activity
Description Thiothixene is a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.
Pathways Neuro Signaling Pathway GPCR/G Protein 
Targets 5 HT Receptor/Serotonin Receptor 

Structure

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